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NXgenPort旨在在症状出现之前检测癌症患者的早期感染迹象_我的网站
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At 29, Shi belongs to a new generation of desert-control workers equipped with drones, machines and remote irrigation systems. An earth auger can now do in a day what once required about 200 laborers, while a single phone can control drip irrigation across more than 1,000 mu (about 66.67 hectares) of woodland.
For the older Shi's generation, the challenge was getting trees to survive in moving dunes. For the grandson, it is figuring out how to make those forests healthier and more resilient for decades to come.
Their story captures a broader shift in desert control along the southern edge of the Maowusu Desert in northwest China's Shaanxi Province: turning shifting sand into forest was only the beginning.
In 1986, Shi Guangyin, Shi Jianyang's grandfather, led more than 300 villagers into Langwosha, a sandy area in Dingbian County in Yulin City. He had raised 60,000 yuan (about 17,377 U.S. dollars at the time) by selling his family's 84 sheep and borrowing from relatives and banks to contract 3,500 mu of barren sandy land.
The early setbacks were severe. Strong winds destroyed about 90 percent of the saplings in the first year, and about 80 percent of those planted the following year failed to survive.
After seeking advice from forestry experts, Shi and the villagers laid out checkerboard-shaped barriers on windward slopes to hold the sand in place, then planted trees, shrubs and grasses within them. Sapling survival rates rose to about 80 percent.
Over the next four decades, Shi and those working alongside him treated 250,000 mu of sandy and saline-alkali land, with more than 53 million trees and shrubs taking root.
Greening the Maowusu Desert is part of a much larger national undertaking. It is one of the three major battlefronts of China's Three-North Shelterbelt Forest Program, a decades-long effort to curb desertification across northern China.
China has made desertification control a national ecological priority. Since 2023, the country has stepped up efforts under the program, with greater emphasis on systematic restoration and on consolidating earlier gains.
Decades after the first trees took root, a new challenge emerged. Poplars planted decades ago for their rapid growth began reaching the end of their life cycle, with large numbers of trees dying, while forests dominated by a single species were more vulnerable to pests and disease.
Making a forest was one challenge. Keeping it healthy for another generation is another.
Shi Jianyang grew up watching his grandfather and father work to hold back the sand. His father, Shi Zhanjun, spent years planting trees alongside Shi Guangyin before dying in a road accident in 2008 while transporting saplings.
As a boy, Shi Jianyang sometimes resented the work that had taken his father. He spent summer holidays in makeshift tents in the sandy land, eating meals gritty with sand. During planting season, his father would return home with painful blisters in his mouth.
Yet he eventually chose forestry himself.
After studying forestry technology in university, Shi returned home in 2020 and began working in desert control. His team, initially made up of just seven or eight young locals, later brought in university graduates with expertise in soil science, landscaping and pest control.
The younger generation faced a different question: not simply how to make trees survive, but how to make a forest last.
Shi and his team spent more than 40 days in a 5,000-mu woodland setting up sample plots, measuring rainfall, studying soil microorganisms and tracking tree lodging. They proposed renewing aging forests with better-planned forest structures and expanded the planting of Mongolian pine, a long-lived evergreen species that had been successfully tested locally.
To date, about 50,000 mu of land has been planted with Mongolian pine. As some trees fail to survive and require replacement in subsequent planting seasons, the cumulative area of planting operations has reached about 65,000 mu.
Technology has also changed daily work. Drones patrol forests from the air, mechanized equipment dig planting pits, and irrigation can be managed remotely. Sapling survival rates, which Shi Guangyin's generation had raised to about 80 percent through improved sand-control and planting methods, have climbed further to about 92 percent with greater mechanization and more precise management.
Shi said the changes can be felt on the ground. Strong sandstorms have become rare, winds are weaker inside the forest, and the ground stays moist longer after rain. Summer days beneath the trees also feel cooler, while morning dew appears more often. The changes lead him to rethink desert control.
His approach also reflects a broader effort in China's desert regions to link ecological restoration with local livelihoods, giving communities a stronger economic stake in protecting restored land.
With his grandfather's support, Shi and his team have been looking for ways to make better use of the restored land as ecological conditions improve. They have developed potato seedlings suited to sandy soil, promoted greenhouse farming, and set up a livestock cooperative, while increasingly growing potatoes, watermelons and peppers on land once prone to losing water and nutrients.
Shi has also turned to livestreaming e-commerce to market potatoes and other local farm produce, while developing forest-based health and leisure projects. More than 2,000 local residents have seen their incomes rise steadily as farming, livestock breeding and other businesses have developed.
"We used to fear the sand and keep away from it. Now we understand it and know how to make use of it," Shi Guangyin said. "Today, there are opportunities to make a living everywhere in this sandy land."
Across Yulin, forest coverage has risen from 1.8 percent in 1949 to 34.8 percent, while shifting dunes that once encroached on villages have been brought under control.
For Shi Jianyang, however, the green landscape is not proof that the work is finished. "Planting a tree is not difficult," he said. "The difficult part is looking after it for decades."
The grandfather generation learned how to stop the sand. The young generation is learning how to make what grew there last.
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B | 该端口的目标是提醒医生注意感染的迹象，减少住院，并收集重要的生理数据以改善病人的预后。NXgenPort是首席执行官兼联合创始人Cathy Skinner的心血结晶，20年前她的父亲因癌症去世后，她根据自己的经验提出了这个端口的想法。
C | 他的诊断结果使Skinner走上了在肿瘤学领域工作的道路，并成为一名癌症运动专家。2016年，她与一名乳腺癌患者一起工作，并注意到她的病情比Skinner最后一次见到她时恶化了。这名患者去看医生，得知她为抗癌而服用的药物也在损害她的心脏。“当她告诉我这个故事时，我看到她胸前有一个植入药物的化疗口，我就想，我们怎么就不能早点知道药物正在损害她的心脏呢？”Skinner在采访中告诉TechCrunch。
D | “我一直知道我有一个好主意，但我需要一个团队来围绕它进行建设。”这时，NXgenPort公司的首席运营官Rosanne Welcher博士和首席技术官Mohamed Ali医学博士开始参与其中。2019年，Skinner在哈佛大学参加一个会议，坐在Welcher旁边吃午饭，两人开始讨论他们的专业。在Skinner发现Welcher是一位在癌症诊断和领导方面拥有25年工作经验的科学家后，她就分享了她对NXgenPort的想法。随后，Skinner和Welcher于2020年5月成立了公司，并向犹他州的一名律师提交了一份非临时专利。
E | 他们的律师曾聘请Ali为该专利绘制产品图纸，之后，Ali分享了他对该产品的兴趣，并以他在康复科学和心脏护理方面的专业知识加入了他们的团队。NXgenPort嵌入了微电子和电池。该设备有光学传感器穿过导管。一旦端口被植入胸部，导管穿过病人的心脏，该设备就会捕捉到血细胞的图像，然后压缩数据并将其发送到云端，之后通过机器学习进行分析。Skinner指出，细胞是由它们的大小和组成来区分的，因此该公司已经训练了算法来计算不同的细胞，然后提供趋势，说明血细胞是以好的还是坏的方式变化。“随着化疗端口的植入，再加上我们嵌入了远程病人监测的技术，我们能够检测到红血球和白血球的变化，心输出量和生命体征，”Skinner说。“现在，如果一个专利需要确定他们是否有资格接受下一次化疗预约，他们必须开车去诊所，并接受血液测试。
F | 如果他们的血细胞计数不正常，他们就不符合条件，必须开车回家。
G | 我们正在进行远程监控，并显示一段时间内的趋势，看看数据是否显示出感染的迹象，如果病人需要提前来输血，或者化疗需要重新安排时间。”NXgenPort仍处于获得美国食品和药物管理局批准的过程中，因此该公司还不能对人类进行测试。
H | 这家初创公司今年将进入动物测试阶段，并从猪开始。Skinner说，这家初创公司预计将在2025年底开始进行人体测试。
I | Skinner表示：“这是一件非常困难和雄心勃勃的事情，我们正在寻求通过采用实验室中用于计数细胞的光学传感器，将它们小型化，并让它们在血流中被激活。所以我们面临着一些重要的挑战，但与此同时，当我们完成这项工作时，它将完全改变癌症患者的监测方式。我们在2025年进入市场的时机将非常合适，因为Hospital at Home模式将更加成熟，我们将准备好进行整合。”在资金方面，这家初创公司在2022年3月完成了预种子轮融资，包括来自联合创始人的朋友和家人、mHUB加速器和Edward-Elmhurst Health Ventures的投资。NXgenPort正在进行400万美元的种子轮融资，但目前无法透露主要投资者。该公司的A轮投资，Skinner说将由1000万美元组成，将在2023年进行。至于该公司的商业模式，Skinner表示，这家初创公司将着眼于向端口制造商、制药商和虚拟诊所试验公司授权该技术。NXgenPort本身的价格将比标准端口高一点，后者的价格通常在270美元左右。除了硬件之外，这家初创公司还将为其软件提供订阅模式，为医生收集和分析结果。Skinner说，该软件的价格约为每月40或50美元，将支付给管理端口的医院。尽管这家初创公司目前专注于癌症，但Skinner说这家初创公司的目标是在未来变成一家拥有不同产品线的公司。这家初创公司认为，在透析、心脏护理和兽医护理方面，带有光学传感器的植入式设备可以收集病人的血液数量和心脏功能，这是个机会。
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